Publications

87Dhume S, Balogun K, Sarkar S, Acosta S, Mount HTJ, Cahill LS, Sled JG, Serghides L. Perinatal exposure to atazanavir-based antiretroviral regimens in a mouse model leads to differential long-term motor and cognitive deficits dependent on the NRTI backbone. Front Mol Neurosci. 2024 Apr 5; 17:1376681. FULL TEXT
PMID:
38646101
86Varo R, Crowley VM, Mucasse H, Sitoe A, Bramugy J, Serghides L, Weckman AM, Erice C, Bila R, Vitorino P, Mucasse C, Valente M, Ajanovic S, Balanza N, Zhong K, Derpsch Y, Gladstone M, Mayor A, Bassat Q, Kain KC. Adjunctive rosiglitazone treatment for severe pediatric malaria: A randomized placebo-controlled trial in Mozambican children. Int J Infect Dis. 2023 Nov 25; 139:34-40.FULL TEXT
PMID:
38013152
85Fisher SA, Jao KJ, Yee LM, Serghides L, Chadwick EG, Jacobson DL. Association of Fatty Acid Signatures with HIV Viremia in Pregnancy. AIDS Res Hum Retroviruses. 2023 Oct 30; 10.1089/AID.2023.0040.FULL TEXT
PMID:
37772708
84Mohan H, Nguyen J, MacKenzie B, Yee A, Laurette EY, Sanghvi T, Tejada O, Dontsova V, Leung KY, Goddard C, De Young T, Sled JG, Greene NDE, Copp AJ, & Serghides L. Folate deficiency increases the incidence of dolutegravir-associated foetal defects in a mouse pregnancy model. EBioMedicine. 2023 Aug 14; 95(104762), 104762.FULL TEXT
PMID:
37586112
83Dontsova V, Mohan H, Blanco C, Jao J, Greene NDE, Copp AJ, Zash R, & Serghides L. Metabolic implications and safety of dolutegravir use in pregnancy. Lancet HIV. 2023 Aug 4; 10(9):e606-e616.FULL TEXT
PMID:
37549681
82Shiau S, Jacobson DL, Huo Y, Kacanek D, Yee LM, Williams DB, Haddad LB, Serghides L, Powis K, Sperling RS, Williams PL, Jao J & Pediatric HIV/AIDS Cohort Study. Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States. J Infect Dis. 2023 Mar 1; 227(5):720-730.FULL TEXT
PMID:
36592383
81Aker A, Serghides L, Cotnam J, Jackson R, Robinson M, Gauvin H, Mushquash C, Gesink D, Amirault M, & Benoit AC. The impact of a stress management intervention including cultural components on stress biomarker levels and mental health indicators among indigenous women. J Infect Dis. 2023 Jan 18.FULL TEXT
PMID:
36652086
80Smith MR, Mohan H, Ajaykumar A, Hsieh AYY, Martineau L, Patel R, Gadawska I, Sherwood C, Serghides L, Piret JM, & Côté HCF. Second-Generation Human Immunodeficiency Virus Integrase Inhibitors Induce Differentiation Dysregulation and Exert Toxic Effects in Human Embryonic Stem Cell and Mouse Models. J Infect Dis. 2022 Nov 28; 226(11):1992-2001.FULL TEXT
PMID:
36124861
79Medeiros P, Warren L, Kazemi M, Massaquoi N, Smith S, Tharao W, Serghides L, Logie CH, Kroch A, Burchell AN, de Pokomandy A, Kaida A, Loutfy M, & CHIWOS Research Team. HIV care cascade for women living with HIV in the Greater Toronto Area versus the rest of Ontario and Canada. Int J STD AIDS. 2022 Nov 21; 34(1):4-17.FULL TEXT
PMID:
36411243
78Saghian R, Cahill LS, Debebe SK, Rahman A, Serghides L, McDonald CR, Weckman AM, Kain KC, & Sled JG. Allometric scaling relationships in mouse placenta. J R Soc Interface. 2022 Nov 9; 19(196):20220579.PDF
PMID:
36349448
77Mohan H, Atkinson K, Watson B, Brumme, CJ, & Serghides L. A Pharmacokinetic Dose-Optimization Study of Cabotegravir and Bictegravir in a Mouse Pregnancy Model. Pharmaceutics. 2022 Aug 24; 14(9):1761. FULL TEXT
PMID:
36145509
76Balogun K, & Serghides L. Comparison of the Effects of Three Dual-Nucleos(t)ide Reverse Transcriptase Inhibitor Backbones on Placenta Mitochondria Toxicity and Oxidative Stress Using a Mouse Pregnancy Model. Pharmaceutics. 2022 May 15; 14(5):1063.FULL TEXT
PMID:
35631648
75Gilmore JC, Hoque MT, Dai W, Mohan H, Dunk C, Serghides L, & Bendayan R. Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta. EBioMedicine. 2021 Dec 23; 75:103771.FULL TEXT
PMID:
34954655
74Kala S, Meteleva K, & Serghides L. ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental Infection. J Infect Dis. 2021 Dec 8; 224(Supplement_6):S631-S641.FULL TEXT
PMID:
33880537
73Dunk CE, & Serghides L. Protease inhibitor-based antiretroviral therapy in pregnancy: effects on hormones, placenta, and decidua. Lancet HIV. 2021 Dec 2; 9(2):e120-e129.FULL TEXT
PMID:
34863352
72Shinar S, Agrawal S, Ryu M, Walmsley S, Serghides L, Yudin MH, & Murphy KE. Perinatal outcomes in women living with HIV-1 and receiving antiretroviral therapy – a systematic review and meta-analysis. Acta Obstet Gynecol Scand. 2021 Oct 27; 101(2):168-182.FULL TEXT
PMID:
34704251
71Roberts DJ, Edlow AG, Romero RJ, Coyne CB, Ting DT, Hornick JL, Zaki SR,
Adhikari UD, Serghides L, Gaw SL, Metz TD; all members of the NIH/NICHD
SARS-CoV-2 Placental Infection Workshop. SPECIAL REPORT: A standardized
definition of placental infection by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), a consensus statement from the National Institutes of Health/Eunice
Kennedy Shriver National Institute of Child Health and Human Development
(NIH/NICHD) SARS-CoV-2 placental infection workshop.
Am J Obstet Gynecol. 2021
Aug 5:S0002-9378(21)00832-2.
FULL TEXT
PMID: 34364845
70Cahill LS, Mercer GV, Jagota D, Ravi Chandran A, Milligan N, Shinar S,
Whitehead CL, Hobson SR, Serghides L, Parks WT, Macgowan CK, Kingdom JC, Sled
JG, Baschat AA. Doppler Ultrasound of the Fetal Descending Aorta: An Objective
Tool to Assess Placental Blood Flow Resistance in Pregnancies with Discordant
Umbilical Arteries.
J Ultrasound Med. 2021 Jul 6.
PDF
PMID: 34228375
69Gilmore JC, Zhang G, Cameron DW, Serghides L, Bendayan R. Impact of in utero
antiretroviral drug exposure on expression of membrane-associated transporters
in mouse placenta and fetal brain.
AIDS 2021 Jun 25.
PDF
PMID: 34175869
68Cahill LS, Stortz G, Ravi Chandran A, Milligan N, Shinar S, Whitehead CL,
Hobson SR, Ayyathurai V, Rahman A, Saghian R, Jobst KJ, McShane C, Block-Abraham
D, Seravalli V, Laurie M, Millard S, Delp C, Wolfson D, Baschat AA, Murphy KE,
Serghides L, Morgen E, Macgowan CK, Parks WT, Kingdom JC, Sled JG. Wave
reflections in the umbilical artery measured by Doppler ultrasound as a novel
predictor of placental pathology.
EBioMedicine 67 (2021) 103326.
FULL TEXT
PMID: 33965347
67Kala S, Meteleva K, Serghides L. ACE2, TMPRSS2 and L-SIGN expression in
placentae from HIV-positive pregnancies exposed to antiretroviral therapy-
implications for SARS-CoV-2 placental infection.
J Infect Dis. 2021 Apr
21:jiab166.
FULL TEXT
PMID: 33880537
66Mohan H, Guzman Lenis M, Laurette EY, Tejada O, Sanghvi T, Leung KY, Cahill
LS, Sled JG, Delgado-Olguín P, Greene NDE, Copp AJ, Serghides L. In response to
the Letter to the Editor by Romach et al. re our publication “Dolutegravir in
pregnant mice is associated with increased rates of fetal defects at therapeutic
but not at supratherapeutic levels”.
EBioMedicine. 2021 Apr;66:103334.
FULL TEXT
PMID: 33862586
65Jagota D, George H, Walker M, Ravi Chandran A, Milligan N, Shinar S,
Whitehead CL, Hobson SR, Serghides L, Parks WT, Baschat AA, Macgowan CK, Sled
JG, Kingdom JC, Cahill LS. Sex differences in fetal Doppler parameters during
gestation.
Biol Sex Differ. 2021 Mar 10;12(1):26.
FULL TEXT
PMID: 33691774
64Paranavitana L, Walker M, Chandran AR, Milligan N, Shinar S, Whitehead CL,
Hobson SR, Serghides L, Parks WT, Baschat AA, Macgowan CK, Sled JG, Kingdom JC,
Cahill LS. Sex differences in uterine artery Doppler during gestation in
pregnancies complicated by placental dysfunction.
Biol Sex Differ. 2021 Feb
2;12(1):19.
FULL TEXT
PMID: 33531040
63Cahill LS, Shinar S, Whitehead CL, Hobson SR, Stortz G, Ayyathurai V, Ravi
Chandran A, Rahman A, Kingdom JC, Baschat A, Murphy KE, Serghides L, Macgowan
CK, Sled JG. Sex differences in modulation of fetoplacental vascular resistance
in growth-restricted mouse fetuses following betamethasone administration:
comparisons with human fetuses.
Am J Obstet Gynecol MFM. 2021 Jan;3(1):100251.
FULL TEXT
PMID: 33451599
62Mohan H, Lenis MG, Laurette EY, Tejada O, Sanghvi T, Leung KY, Cahill LS,
Sled JG, Delgado-Olguín P, Greene NDE, Copp AJ, Serghides L. Dolutegravir in
pregnant mice is associated with increased rates of fetal defects at therapeutic
but not at supratherapeutic levels.
EBioMedicine. 2021 Jan;63:103167.
FULL TEXT
PMID: 33341441
61Yampolsky M, Shlakhter O, Deng D, Kala S, Walmsley SL, Murphy KE, Yudin MH,
MacGillivray J, Loutfy M, Dunk C, Serghides L. Exploring the impact of HIV
infection and antiretroviral therapy on placenta morphology.
Placenta. 2021 Jan
15;104:102-109.
FULL TEXT
PMID: 33310298
60Sarkar A, Balogun K, Guzman Lenis MS, Acosta S, Mount HT, Serghides L. In
utero exposure to protease inhibitor-based antiretroviral regimens delays growth
and developmental milestones in mice.
PLoS One. 2020 Nov 19;15(11):e0242513.
FULL TEXT
PMID: 33211746
59Kojovic D, Ghoneim RH, Serghides L, Piquette-Miller M. Role of HIV and
Antiretroviral Therapy on the Expression of Placental Transporters in Women with
HIV.
AAPS J. 2020 Oct 25;22(6):138.
PMID: 33099683
58Gilmore JC, Serghides L, Bendayan R. Differential effects of antiretroviral
drug toxicity in male versus female children who are HIV-exposed but uninfected.

AIDS. 2021 Jan 1;35(1):1-14.
PMID: 33048885
57Kala S, Dunk C, Acosta S, Serghides L. Periconceptional exposure to
lopinavir, but not darunavir, impairs decidualization: a potential mechanism
leading to poor birth outcomes in HIV-positive pregnancies.
Hum Reprod. 2020 Aug
1;35(8):1781-1796.
FULL TEXT
PMID: 32712670
56Debebe SK, Cahill LS, Kingdom JC, Whitehead CL, Chandran AR, Parks WT,
Serghides L, Baschat A, Macgowan CK, Sled JG. Wharton’s jelly area and its
association with placental morphometry and pathology.
Placenta. 2020
May;94:34-38.
FULL TEXT
PMID: 32421532
55Cahill LS, Whitehead CL, Hobson SR, Stortz G, Kingdom JC, Baschat A, Murphy
KE, Serghides L, Macgowan CK, Sled JG. Effect of maternal betamethasone
administration on feto-placental vascular resistance in the mouse†.
Biol Reprod.
2019 Oct 25;101(4):823-831.
FULL TEXT
PMID: 31318405
54McHenry MS, Balogun KA, McDonald BC, Vreeman RC, Whipple EC, Serghides L.
In utero exposure to HIV and/or antiretroviral therapy: a systematic review of
preclinical and clinical evidence of cognitive outcomes.
J Int AIDS Soc. 2019
Apr;22(4):e25275.
FULL TEXT
PMID: 30983111
53Sled JG, Stortz G, Cahill LS, Milligan N, Ayyathurai V, Serghides L, Morgen
E, Seravalli V, Delp C, McShane C, Baschat A, Kingdom J, Macgowan CK. Reflected
hemodynamic waves influence the pattern of Doppler ultrasound waveforms along
the umbilical arteries.
Am J Physiol Heart Circ Physiol. 2019 May
1;316(5):H1105-H1112.
FULL TEXT
PMID: 30794433
52Cahill LS, Zhou YQ, Hoggarth J, Yu LX, Rahman A, Stortz G, Whitehead CL,
Baschat A, Kingdom JC, Macgowan CK, Serghides L, Sled JG. Placental vascular
abnormalities in the mouse alter umbilical artery wave reflections.
Am J Physiol
Heart Circ Physiol. 2019 Mar 1;316(3):H664-H672.
FULL TEXT
PMID: 30632765
51Kala S, Watson B, Zhang JG, Papp E, Guzman Lenis M, Dennehy M, Cameron DW,
Harrigan PR, Serghides L. Improving the clinical relevance of a mouse pregnancy
model of antiretroviral toxicity; a pharmacokinetic dosing-optimization study of
current HIV antiretroviral regimens.
Antiviral Res. 2018 Nov;159:45-54.
PMID: 30236532
50Slogrove AL, Becquet R, Chadwick EG, Côté HCF, Essajee S, Hazra R, Leroy V,
Mahy M, Murenga M, Wambui Mwangi J, Oyiengo L, Rollins N, Penazzato M, Seage GR
3rd, Serghides L, Vicari M, Powis KM. Surviving and Thriving-Shifting the Public
Health Response to HIV-Exposed Uninfected Children: Report of the 3rd HIV-
Exposed Uninfected Child Workshop.
Front Pediatr. 2018 May 30;6:157.
FULL TEXT
PMID: 29900165
49Mohammadi H, Papp E, Cahill L, Rennie M, Banko N, Pinnaduwage L, Lee J,
Kibschull M, Dunk C, Sled JG, Serghides L. HIV antiretroviral exposure in
pregnancy induces detrimental placenta vascular changes that are rescued by
progesterone supplementation.
Sci Rep. 2018 Apr 26;8(1):6552.
FULL TEXT
PMID: 29700323
48Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Kain KC, Bassat Q.
Adjunctive therapy for severe malaria: a review and critical appraisal. Malar J.
2018 Jan 24;17(1):47.
FULL TEXT
PMID: 29361945
47Wong JMH, Kanga N, Dogra N, Ngoma MS, Serghides L, Silverman M. Perceived
acceptability of progesterone to prevent preterm births and low birth weight
among HIV-infected and HIV-uninfected Zambian pregnant women.
Int J Womens
Health. 2017 Nov 16;9:827-833.
FULL TEXT
PMID: 29180906
46McDonald CR, Conroy AL, Gamble JL, Papp E, Hawkes M, Olwoch P, Natureeba P,
Kamya M, Silverman M, Cohan D, Koss CA, Dorsey G, Kain KC, Serghides L.
Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant
Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral
Therapy.
Clin Infect Dis. 2018 Jan 18;66(3):428-436.
FULL TEXT
PMID: 29136115
45Balogun KA, Guzman Lenis MS, Papp E, Loutfy M, Yudin MH, MacGillivray J,
Walmsley SL, Silverman M, Serghides L. Elevated Levels of Estradiol in Human
Immunodeficiency Virus-Infected Pregnant Women on Protease Inhibitor-Based
Regimens.
Clin Infect Dis. 2018 Jan 18;66(3):420-427.
FULL TEXT
PMID: 29020282
44Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Bila R, Mucavele H,
Mayor A, Bassat Q, Kain KC. Safety and tolerability of adjunctive rosiglitazone
treatment for children with uncomplicated malaria.
Malar J. 2017 May
23;16(1):215.
FULL TEXT
PMID: 28535809
43Kennedy VL, Collins M, Yudin MH, Serghides L, Walmsley S, Angel JB, Ongoiba
F, Powis J, Smaill F, Tharao W, Rachlis A, Silverman M, Sandre R, Regier DA,
Loutfy M. Exploring the Factors Considered by People Living with HIV and Their
Partners during Preconception.
J Int Assoc Provid AIDS Care. 2017
May/Jun;16(3):239-246.
FULL TEXT
PMID: 28485707
42Siou K, Walmsley SL, Murphy KE, Raboud J, Loutfy M, Yudin MH, Silverman M,
Ladhani NN, Papp E, Serghides L. Erratum to: Progesterone supplementation for
HIV-positive pregnant women on protease inhibitor-based antiretroviral regimens
(the ProSPAR study): a study protocol for a pilot randomized controlled trial.

Pilot Feasibility Stud. 2017 Apr 28;3:21. (Erratum for: Pilot Feasibility Stud. 2016
Aug 12;2:49.)
FULL TEXT
PMID: 28461906
41Siou K, Walmsley SL, Murphy KE, Raboud J, Loutfy M, Yudin MH, Silverman M,
Ladhani NN, Serghides L. Progesterone supplementation for HIV-positive pregnant
women on protease inhibitor-based antiretroviral regimens (the ProSPAR study): a
study protocol for a pilot randomized controlled trial.
Pilot Feasibility Stud.
2016 Aug 12;2:49. (Erratum in: Pilot Feasibility Stud. 2017 Apr 28;3:21.)
FULL TEXT
PMID: 27965866
40Ayi K, Lu Z, Serghides L, Ho JM, Finney C, Wang JCY, Liles WC, Kain KC.
CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-
Infected Erythrocytes and Clearance of Malaria In Vivo.
Infect Immun. 2016 Jun
23;84(7):2002-2011.
FULL TEXT
PMID: 27091932
39Papp E, Balogun K, Banko N, Mohammadi H, Loutfy M, Yudin MH, Shah R,
MacGillivray J, Murphy KE, Walmsley SL, Silverman M, Serghides L. Low Prolactin
and High 20-α-Hydroxysteroid Dehydrogenase Levels Contribute to Lower
Progesterone Levels in HIV-Infected Pregnant Women Exposed to Protease
Inhibitor-Based Combination Antiretroviral Therapy.
J Infect Dis. 2016 May
15;213(10):1532-40.
FULL TEXT
PMID: 26740274
38Finney C, Serghides L. An In Vitro Model for Measuring Immune Responses to
Malaria in the Context of HIV Co-infection.
J Vis Exp. 2015 Oct 6;(104):52969.
FULL TEXT
PMID: 26485041
37Serghides L, Finney CA, Ayi K, Loutfy M, Kain KC. Chronic HIV infection
impairs nonopsonic phagocytosis of malaria parasites.
J Acquir Immune Defic
Syndr. 2015 Feb 1;68(2):128-32.
FULL TEXT
PMID: 25415293
36Papp E, Mohammadi H, Loutfy MR, Yudin MH, Murphy KE, Walmsley SL, Shah R,
MacGillivray J, Silverman M, Serghides L. HIV protease inhibitor use during
pregnancy is associated with decreased progesterone levels, suggesting a
potential mechanism contributing to fetal growth restriction.
J Infect Dis. 2015
Jan 1;211(1):10-8.
FULL TEXT
PMID: 25030058
35Serghides L, McDonald CR, Lu Z, Friedel M, Cui C, Ho KT, Mount HT, Sled JG,
Kain KC. PPARγ agonists improve survival and neurocognitive outcomes in
experimental cerebral malaria and induce neuroprotective pathways in human
malaria.
PLoS Pathog. 2014 Mar 6;10(3):e1003980.
FULL TEXT
PMID: 24603727
34Chege D, Higgins SJ, McDonald CR, Shahabi K, Huibner S, Kain T, Kain D, Kim
CJ, Leung N, Amin M, Geddes K, Serghides L, Philpott DJ, Kimani J, Gray-Owen S,
Kain KC, Kaul R. Murine Plasmodium chabaudi malaria increases mucosal immune
activation and the expression of putative HIV susceptibility markers in the gut
and genital mucosae.
J Acquir Immune Defic Syndr. 2014 Apr 15;65(5):517-25.
FULL TEXT
PMID: 24256632
33Kennedy VL, Serghides L, Raboud JM, Su D, Blitz S, Hart TA, Walmsley SL,
Angel JB, Smaill FM, Ralph ED, Tharao WE, Loutfy MR; Ontario HIV Fertility
Research Team. The importance of motherhood in HIV-positive women of
reproductive age in Ontario, Canada.
AIDS Care. 2014;26(6):777-84.
PMID: 24206065
32Kim H, Erdman LK, Lu Z, Serghides L, Zhong K, Dhabangi A, Musoke C, Gerard
C, Cserti-Gazdewich C, Liles WC, Kain KC. Functional roles for C5a and C5aR but
not C5L2 in the pathogenesis of human and experimental cerebral malaria.
Infect
Immun. 2014 Jan;82(1):371-9.
FULL TEXT
PMID: 24191300
31Finney CA, Ayi K, Wasmuth JD, Sheth PM, Kaul R, Loutfy M, Kain KC, Serghides
L. HIV infection deregulates Tim-3 expression on innate cells: combination
antiretroviral therapy results in partial restoration.
J Acquir Immune Defic
Syndr. 2013 Jun 1;63(2):161-7.
FULL TEXT
PMID: 23314411
30Finney CA, Ayi K, Wasmuth JD, Sheth PM, Kaul R, Loutfy MR, Kain KC,
Serghides L. HIV infection deregulates innate immunity to malaria despite
combination antiretroviral therapy.
AIDS. 2013 Jan 28;27(3):325-35.
FULL TEXT
PMID: 23291537
29Miller C, Miller M, McMullin B, Regev G, Serghides L, Kain K, Road J, Av-Gay
Y. A phase I clinical study of inhaled nitric oxide in healthy adults. J Cyst
Fibros. 2012 Jul;11(4):324-31.
FULL TEXT
PMID: 22520076
28Serghides L, Kim H, Lu Z, Kain DC, Miller C, Francis RC, Liles WC, Zapol WM,
Kain KC. Inhaled nitric oxide reduces endothelial activation and parasite
accumulation in the brain, and enhances survival in experimental cerebral
malaria.
PLoS One. 2011;6(11):e27714.
FULL TEXT
PMID: 22110737
27Serghides L. The Case for the Use of PPARγ Agonists as an Adjunctive Therapy
for Cerebral Malaria.
PPAR Res. 2012;2012:513865.
FULL TEXT
PMID: 21772838
26Hawkes M, Opoka RO, Namasopo S, Miller C, Conroy AL, Serghides L, Kim H,
Thampi N, Liles WC, John CC, Kain KC. Nitric oxide for the adjunctive treatment
of severe malaria: hypothesis and rationale.
Med Hypotheses. 2011
Sep;77(3):437-44.
FULL TEXT
PMID: 21745716
25Labbé K, Miu J, Yeretssian G, Serghides L, Tam M, Finney CA, Erdman LK,
Goulet ML, Kain KC, Stevenson MM, Saleh M. Caspase-12 dampens the immune
response to malaria independently of the inflammasome by targeting NF-kappaB
signaling.
J Immunol. 2010 Nov 1;185(9):5495-502.
FULL TEXT
PMID: 20876354
24Stevenson MM, Gros P, Olivier M, Fortin A, Serghides L. Cerebral malaria:
human versus mouse studies.
Trends Parasitol. 2010 Jun;26(6):274-5.
PMID: 20382077
23Boggild AK, Krudsood S, Patel SN, Serghides L, Tangpukdee N, Katz K,
Wilairatana P, Liles WC, Looareesuwan S, Kain KC. Use of peroxisome
proliferator-activated receptor gamma agonists as adjunctive treatment for
Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled
trial.
Clin Infect Dis. 2009 Sep 15;49(6):841-9.
FULL TEXT
PMID: 19673614
22Serghides L, Patel SN, Ayi K, Lu Z, Gowda DC, Liles WC, Kain KC.
Rosiglitazone modulates the innate immune response to Plasmodium falciparum
infection and improves outcome in experimental cerebral malaria.
J Infect Dis.
2009 May 15;199(10):1536-45.
FULL TEXT
PMID: 19392627
21Conroy A, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC,
Moore JM, Kain KC. C5a enhances dysregulated inflammatory and angiogenic
responses to malaria in vitro: potential implications for placental malaria.

PLoS One. 2009;4(3):e4953.
FULL TEXT
PMID: 19308263
20Patel SN, Berghout J, Lovegrove FE, Ayi K, Conroy A, Serghides L, Min-oo G,
Gowda DC, Sarma JV, Rittirsch D, Ward PA, Liles WC, Gros P, Kain KC. C5
deficiency and C5a or C5aR blockade protects against cerebral malaria.
J Exp
Med. 2008 May 12;205(5):1133-43.
FULL TEXT
PMID: 18426986
19Ayi K, Min-Oo G, Serghides L, Crockett M, Kirby-Allen M, Quirt I, Gros P,
Kain KC. Pyruvate kinase deficiency and malaria. N Engl J Med. 2008 Apr
24;358(17):1805-10.
FULL TEXT
PMID: 18420493
18Keen J, Serghides L, Ayi K, Patel SN, Ayisi J, van Eijk A, Steketee R,
Udhayakumar V, Kain KC. HIV impairs opsonic phagocytic clearance of pregnancy-
associated malaria parasites.
PLoS Med. 2007 May;4(5):e181.
FULL TEXT
PMID: 17535103
17Patel SN, Lu Z, Ayi K, Serghides L, Gowda DC, Kain KC. Disruption of CD36
impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol
and confers susceptibility to severe and fatal malaria in vivo.
J Immunol. 2007
Mar 15;178(6):3954-61.
FULL TEXT
PMID: 17339496
16Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC,
Karin M, Kain KC. Disruption of JNK2 decreases the cytokine response to
Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers
protection in a cerebral malaria model.
J Immunol. 2006 Nov 1;177(9):6344-52.
FULL TEXT
PMID: 17056565
15Serghides L, Vidric M, Watts TH. Approaches to studying costimulation of
human antiviral T cell responses: prospects for immunotherapeutic vaccines.

Immunol Res. 2006;35(1-2):137-50.
PMID: 17003516
14Serghides L, Patel SN, Ayi K, Kain KC. Placental chondroitin sulfate
A-binding malarial isolates evade innate phagocytic clearance.
J Infect Dis.
2006 Jul 1;194(1):133-9.
FULL TEXT
PMID: 16741892
13Serghides L, Bukczynski J, Wen T, Wang C, Routy JP, Boulassel MR, Sekaly RP,
Ostrowski M, Bernard NF, Watts TH. Evaluation of OX40 ligand as a costimulator
of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL.

J Immunol. 2005 Nov 15;175(10):6368-77.
FULL TEXT
PMID: 16272289
12Ayi K, Patel SN, Serghides L, Smith TG, Kain KC. Nonopsonic phagocytosis of
erythrocytes infected with ring-stage Plasmodium falciparum.
Infect Immun. 2005
Apr;73(4):2559-63.
FULL TEXT
PMID: 15784606
11Serghides L, Kain KC. Peroxisome proliferator-activated receptor gamma and
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Lancet. 2002 Apr 20;359(9315):1404-6.
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